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Peptide record

TPDB62839

XC2 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB62839
XC2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KVRVRVRVPIGTRVRERVK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C100H187N39O23
ANDCQHLMFSWY
RV
2303.83
12.71
8
1
7
+7
4.21
-0.595
112.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
1
I
0
L
2
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
6
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 6
Chemical Descriptors
19 main sequence record
C100H187N39O23 sequence-only estimate (linear, free termini)
2303.83 sequence-only estimate (linear, free termini)
12.71 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
4.21 sequence-only estimate (linear, free termini)
-0.595 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic and amphiphilic Activity
Linear Activity
Free Activity
N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphiphilic
Synthetic
NHS-fluorescein and EGFP protein
Cytoplasm
Had modest increases in overall uptake compared to CLIP6
Energy-dependent processes and direct translocation
In vitro
CCSCCCCSGGGCCCCSCC
Additional Detail Fields 1 fields
CCSCCCCSGGGCCCCSCC