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Peptide record

TPDB62838

XS1 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB62838
XS1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KVKVKVKYNGTKVKVKVK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C97H177N27O22
ARDCEQHILMFPSW
K
2073.64
11.02
8
0
7
+8
1.59
-0.661
96.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
0.72
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
8
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
6
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 8 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 6
Chemical Descriptors
18 main sequence record
C97H177N27O22 sequence-only estimate (linear, free termini)
2073.64 sequence-only estimate (linear, free termini)
11.02 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
1.59 sequence-only estimate (linear, free termini)
-0.661 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic and amphiphilic Activity
Linear Activity
Free Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic and amphiphilic
Synthetic
NHS-fluorescein and EGFP protein
Cytoplasm
Had greater uptake than XS2
Clathrin mediated endocytosis
In vitro