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Peptide record

TPDB62830

KST Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB62830
KST
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Conjugation with Avidin-FITC
Sequence
KSTGKANKITITNDKGRLSK
Physicochemical Analysis
C91H166N30O30
CEQHMFPWYV
K
2160.50
11.10
6
1
4
+5
7.18
-1.220
63.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
7
Residue Composition
number
1
A
1
R
2
N
1
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
5
K
0
M
0
F
0
P
2
S
3
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 5 M: 0 F: 0 P: 0 S: 2 T: 3 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C91H166N30O30
2160.50
11.10
+5
7.18
-1.220
Conjugation with Avidin-FITC
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

K-562, A-431, T98G, and 3T3 and 3T3-SV-40

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Protein (Avidin-FITC)
Cytoplasm
KST peptide demonstrated profound penetration into the cells of both lines with the same efficiency as the full-length chap- erone tagged with Alexa488
In vitro
CCCCCCCCCCCCCBTTTBCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCCBTTTBCC