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Peptide record

TPDB62829

α1H Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB62829
α1H
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
KSKTEYYNAWAVWERNAPC
Physicochemical Analysis
C105H150N28O30S1
DQGHILMF
A
2316.58
8.80
3
2
8
+1
2.13
-1.142
31.05
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
13980
603.48
7
Residue Composition
number
3
A
1
R
2
N
0
D
1
C
2
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
1
P
1
S
1
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 2 D: 0 C: 1 E: 2 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 1 T: 1 W: 2 Y: 2 V: 1
Chemical Descriptors
19
C105H150N28O30S1
2316.58
8.80
+1
2.13
-1.142
Free
L
Hydrophobic
Linear
Conjugated with FITC
N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa , Hbmec E. Coli K1, Salmonella, And Shigella

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Protein derived
FITC dye and Gentamicin
Cytoplasm
α2H-FITC showed less efficient uptake for α1H-FITC
More than one endocytosis pathways and direct translocation
In vitro
CTHHHHSSCCTTSCCCC
Additional Detail Fields 1 fields
CTHHHHSSCCTTSCCCC