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Peptide record

TPDB62828

PepH4 Blood-Brain Barrier Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB62828
PepH4
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 23-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KSKAINVLRGFRKEIGRMLNILN
Physicochemical Analysis
C118H208N38O30S1
DCQHPTWY
RNILK
2671.25
12.14
6
1
10
+5
4.76
-0.226
118.70
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
1
A
3
R
3
N
0
D
0
C
1
E
0
Q
2
G
0
H
3
I
3
L
3
K
1
M
1
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 3 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 3 M: 1 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C118H208N38O30S1
2671.25
12.14
+5
4.76
-0.226
Free
L
Linear
Hydrophobic
Linear
Free
Similarity
Cationic
LysSerLysAlaIleAsnValLeuArgGlyPheArgLysGluIleGlyArgMetLeuAsnIleLeuAsn
N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

bEND cell line

Assay & Model

5 microCi/ml
Gamma counter radioactivity measure for TcPz
63.45+/- 1.90
Origin/Source

Source & Reference

NA
B3Pdb

Other

Derived from dengue virus capsid
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
Evidence 2 Activity

Activity

Blood-Brain Barrier

Target

bEND cell line

Assay & Model

5 microCi/ml
Gamma counter radioactivity measure for gaNODA
60.79 +/- 2.60
Origin/Source

Source & Reference

NA
B3Pdb

Other

Derived from dengue virus capsid
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
Evidence 3 Activity

Activity

Blood-Brain Barrier
63.45%

Assay & Model

Initial concentration in donor chamber-Culture
Origin/Source
Translocated

Source & Reference

NA
B3Pdb

Other

viral
Permeability
63.45%
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Protein derived
Radiolabelled using fac-[99mTc(CO)3(H2O)3]+ and 67-Ga-labeled
PepH4 had moderate membrane retention and low internalization (10.2±0.8 and 2.8±0.2 %, respectively) and high BEB translocation (63.4±1.9 % after 24h).
In vitro
CCSCSCC
Additional Detail Fields 1 fields
CCSCSCC