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Peptide record

TPDB62821

Z15 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB62821
Z15
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KRYKNRVASRKSRAK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C78H142N32O20
DCEQGHILMFPTW
RK
1848.19
12.42
8
0
4
+8
5.85
-2.147
32.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
0.81
4
Residue Composition
number
2
A
4
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
15 main sequence record
C78H142N32O20 sequence-only estimate (linear, free termini)
1848.19 sequence-only estimate (linear, free termini)
12.42 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
5.85 sequence-only estimate (linear, free termini)
-2.147 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dcs(Human And Mouse) , El4 And K562 Cells

Assay & Model

EG7-OVA cells bearing Female C57BL/6J mice
EG7-OVA cells bearing Female C57BL/6J mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
MART1 epitope , OVACD4 epitope and OVACD8 epitope
Cell line-dependent transduction efficacy
In vitro and in vivo
CCGGGTTCSHHHHHHHHTTCCTTTTSCC
Additional Detail Fields 1 fields
CCGGGTTCSHHHHHHHHTTCCTTTTSCC