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Peptide record

TPDB62819

hClock-(35-47) Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB62819
hClock-(35-47)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with FITC
Sequence
KRVSRNKSEKKRR
Physicochemical Analysis
C68H130N30O19
ADCQGHILMFPTWY
RK
1671.97
12.42
8
1
1
+7
9.97
-2.923
22.31
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
4
R
1
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C68H130N30O19
1671.97
12.42
+7
9.97
-2.923
L
Cationic
Linear
Conjugation with FITC
N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

ECV-304 and the primary neuroglial cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (FITC)
Cytoplasm and nucleus, but mainly in the nucleus with a nucleolar accumula
Similar to Tat (48-60)
Non-endocytic mechanism
In vitro
CCCCCCEETTEEC
Additional Detail Fields 1 fields
CCCCCCEETTEEC