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Peptide record

TPDB62816

Oligoarginine Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB62816
Oligoarginine
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Lysine Residue
Sequence
KRRRRRRRRRC-NH2
Physicochemical Analysis
C63H127N39O12S1
ANDEQGHILMFPSTWYV
R
1655.02
12.95
10
0
0
+10
8.04
-3.809
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
9
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C63H127N39O12S1
1655.02
12.95
+10
8.04
-3.809
Amidation
L
Cationic
Linear
Lysine Residue
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mouse Germinal Vesicle (Gv, Immature) And Metaphase Ii (Mii, Mature) Oocytes

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
5-FAM(5-carboxyfluorescein) conjugated on Lys residue
Cytoplasm
FAM-CPP internalize in concentration-dependent manner in both zona pellucida and the plasma membrane of MII oocytes (with and without ZP) with the flattened method.
Direct translocation
In vitro
CCSSCC
Additional Detail Fields 1 fields
CCSSCC