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Peptide record

TPDB62801

(R5K2) Cell-penetrating Peptides modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB62801
(R5K2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 7-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Fatty acyl chains (C2-C18)
Sequence
KRKRRRR
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
7 main sequence record
Free Activity
Fatty acyl chains (C2-C18) Activity
L Activity
Amphipathic Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 And MDA-MB-435

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
FAM-siRNA
LP-C16 and LP-C18 showed a more significant siRNA uptake than other linear peptide conjugates at a peptide/siRNA ratio of 20:1 and DOPE increased uptake from 53 to 96% at 20:1 for LP-C16 and from 51 to 78% for LP-C18/siRNA w/w ratio of 20:1.
In vitro
CCCCCCCCCSSCC
Additional Detail Fields 1 fields
CCCCCCCCCSSCC