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Peptide record

TPDB62801

(R5K2) Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB62801
(R5K2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 7-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Fatty acyl chains (C2-C18)
Sequence
KRKRRRR
Physicochemical Analysis
C42H86N24O8
ANDCEQGHILMFPSTWYV
R
1055.30
13.01
7
0
0
+7
6.03
-4.329
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C42H86N24O8
1055.30
13.01
+7
6.03
-4.329
Free
Fatty acyl chains (C2-C18)
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 And MDA-MB-435

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
FAM-siRNA
LP-C16 and LP-C18 showed a more significant siRNA uptake than other linear peptide conjugates at a peptide/siRNA ratio of 20:1 and DOPE increased uptake from 53 to 96% at 20:1 for LP-C16 and from 51 to 78% for LP-C18/siRNA w/w ratio of 20:1.
In vitro
CCCCCCCCCSSCC
Additional Detail Fields 1 fields
CCCCCCCCCSSCC