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Peptide record

TPDB62797

HBP Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB62797
HBP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KRKKKGKGLGKKRDPCLRKYK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C111H203N39O25S1
ANEQHIMFSTWV
K
2516.14
11.33
12
1
3
+11
4.27
-2.195
37.14
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
0.59
2
Residue Composition
number
0
A
3
R
0
N
1
D
1
C
0
E
0
Q
3
G
0
H
0
I
2
L
9
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 9 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21 main sequence record
C111H203N39O25S1 sequence-only estimate (linear, free termini)
2516.14 sequence-only estimate (linear, free termini)
11.33 sequence-only estimate (linear, free termini)
+11 sequence-only estimate (linear, free termini)
4.27 sequence-only estimate (linear, free termini)
-2.195 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, 95D, MCF-7, And Mgc80-3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Alpha-momorcharin (α-MMC)
Cytoplasm
α-MMC-HBP significantly accumulated inside the cytoplasm of HeLa cells, whereas small amount of α-MMC was located in HeLa cells.
In vitro
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC