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Peptide record

TPDB62795

VP8 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62795
VP8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
KRKGRLRSKGKK-NH2
Physicochemical Analysis
C61H120N26O14
ANDCEQHIMFPTWYV
K
1441.79
12.72
8
0
1
+8
6.97
-2.567
32.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
1
L
5
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 5 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C61H120N26O14
1441.79
12.72
+8
6.97
-2.567
Amidation
L
Linear
Conjugated with 6-Carboxyfluorescein (6-Fam)
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87, PC3, And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM-conjugated
Showed fluorescent signal in more than 10% of the cells.
In vitro
CCCCCCCCCCTTSCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCTTSCCCCCC