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Peptide record

TPDB62781

Crotalicidin (Ctn) Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB62781
Crotalicidin (Ctn)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 5(6)-Carboxyfluorescein (CF)
Sequence
KRFKKRRKKVKKSVKKRLKKIFKKPMVIGVTIPF-NH2
Physicochemical Analysis
C197H351N59O37S1
ANDCEQHWY
K
4170.39
12.91
17
0
12
+17
12.46
-0.865
80.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
1
L
13
K
1
M
3
F
2
P
1
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 13 M: 1 F: 3 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
34
C197H351N59O37S1
4170.39
12.91
+17
12.46
-0.865
Amidation
L
Cationic
Linear
Conjugated with 5(6)-Carboxyfluorescein (CF)
N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@@H]1C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U937 And PBMCs

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
CF dye
Cytoplasmic Membrane And Nucleus
CF-Ctn uptake was already visible at 6.25 μM in a dose-dependent manner.
Direct translocation and endocytosis (clathrin-mediated endocytosis)
In vitro
CCSSSCTTSSCCCSSSCCCC
Additional Detail Fields 1 fields
CCSSSCTTSSCCCSSSCCCC