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Peptide record

TPDB62781

Crotalicidin (Ctn) Cell-penetrating Peptides modified_plain modified
34 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB62781
Crotalicidin (Ctn)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 34-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 5(6)-Carboxyfluorescein (CF)
Sequence
KRFKKRRKKVKKSVKKRLKKIFKKPMVIGVTIPF-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
34 main sequence record
Amidation Activity
L Activity
Cationic Activity
Linear Activity
Conjugated with 5(6)-Carboxyfluorescein (CF) Activity
N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@@H]1C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U937 And PBMCs

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
CF dye
Cytoplasmic Membrane And Nucleus
CF-Ctn uptake was already visible at 6.25 μM in a dose-dependent manner.
Direct translocation and endocytosis (clathrin-mediated endocytosis)
In vitro
CCSSSCTTSSCCCSSSCCCC
Additional Detail Fields 1 fields
CCSSSCTTSSCCCSSSCCCC