Back to search

Peptide record

TPDB62777

CHAP-1 Cell-penetrating Peptides modified_plain modified
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62777
CHAP-1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 12-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Modified, details unspecified
Sequence
KRBIRLFTKBLK
Physicochemical Analysis
C61H111N19O12
ANDCEQGHMPSWYV
K
1302.67
12.43
5
0
4
+5
2.17
-0.542
97.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
3
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C61H111N19O12
1302.67
12.43
+5
2.17
-0.542
Free
L
Cationic and amphipathic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231, HeLa, U2Os-Lamp-Rflp Cells, And Hek-293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic and amphipathic
Synthetic
5(6)-carboxyfluorescein and Methotrexate (MTX)
Lysosomes, Endosomes and Cytosol
Uptake was more than that of the TAT
Membrane-based pathways
In vitro