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Peptide record

TPDB62776

Yeast GCN 4 (231-252) Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62776
Yeast GCN 4 (231-252)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with fluorescein by C-terminal Gly Cys amide
Sequence
KRARNTEAARRSRARKLQRMKQGC
Physicochemical Analysis
C114H211N51O32S2
DHIFPWYV
R
2872.37
12.53
10
1
6
+9
10.81
-1.821
32.92
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
6
Residue Composition
number
4
A
7
R
1
N
0
D
1
C
1
E
2
Q
1
G
0
H
0
I
1
L
3
K
1
M
0
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 7 N: 1 D: 0 C: 1 E: 1 Q: 2 G: 1 H: 0 I: 0 L: 1 K: 3 M: 1 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C114H211N51O32S2
2872.37
12.53
+9
10.81
-1.821
Conjugation with fluorescein by C-terminal Gly Cys amide
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

RAW 264.7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus
Less relative to Tat-(48–60) peptide
Non-endocytic mechanism
In vitro
CCCCCCTTHHHHHHHHHTTTTCCC
Additional Detail Fields 1 fields
CCCCCCTTHHHHHHHHHTTTTCCC