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Peptide record

TPDB62768

SN21-LK15 Cell-penetrating Peptides modified_plain modified
38 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB62768
SN21-LK15
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 38-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KPVSLSYRCPCRFFESHVARAGGKLLKLLLKLLLKLLK-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
38 main sequence record
Amidation Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Gl3 Firefly Luciferase (HeLa-Gl3) And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
siRNA against luciferase (siLuc) , (IgG-AF488), dHax3-VP64
Cytosol
HeLa cells with 100 μg/mL IgG- AF488 cotreated with 2 μM SN21−LK15 showed uniformly distributed throughout the cytosol while Neither the treatment with 5 μM SN21 nor 2 μM LK15 showed such cytosolic signals.
Macropinocytosis
In vitro
CCSCCCCCCCHHHHTSSSCC
Additional Detail Fields 1 fields
CCSCCCCCCCHHHHTSSSCC