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Peptide record

TPDB62768

SN21-LK15 Cell-penetrating Peptides standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB62768
SN21-LK15
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 38-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KPVSLSYRCPCRFFESHVARAGGKLLKLLLKLLLKLLK-NH2
Physicochemical Analysis
C203H345N55O45S2
NDQIMTW
L
4340.43
10.85
10
1
18
+8
2.62
0.345
133.42
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1615
37.21
6
Residue Composition
number
2
A
3
R
0
N
0
D
2
C
1
E
0
Q
2
G
1
H
0
I
11
L
6
K
0
M
2
F
2
P
3
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 11 K: 6 M: 0 F: 2 P: 2 S: 3 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
38
C203H345N55O45S2
4340.43
10.85
+8
2.62
0.345
Amidation
L
Linear
Free
N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Gl3 Firefly Luciferase (HeLa-Gl3) And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
siRNA against luciferase (siLuc) , (IgG-AF488), dHax3-VP64
Cytosol
HeLa cells with 100 μg/mL IgG- AF488 cotreated with 2 μM SN21−LK15 showed uniformly distributed throughout the cytosol while Neither the treatment with 5 μM SN21 nor 2 μM LK15 showed such cytosolic signals.
Macropinocytosis
In vitro
CCSCCCCCCCHHHHTSSSCC
Additional Detail Fields 1 fields
CCSCCCCCCCHHHHTSSSCC