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Peptide record

TPDB62767

SN21 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB62767
SN21
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KPVSLSYRCPCRFFESHVARA-NH2
Physicochemical Analysis
C109H169N33O28S2
NDQGIMTW
RS
2453.87
9.79
5
1
8
+3
3.25
-0.219
55.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1615
65.81
6
Residue Composition
number
2
A
3
R
0
N
0
D
2
C
1
E
0
Q
0
G
1
H
0
I
1
L
1
K
0
M
2
F
2
P
3
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 1 M: 0 F: 2 P: 2 S: 3 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
21
C109H169N33O28S2
2453.87
9.79
+3
3.25
-0.219
Amidation
L
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorescein-labeled 70 kDa dextran (Dex70-FL)
Cytosol
SN21 stimulated ∼30% higher Dex70-FL uptake than HIV-1 TAT and octaarginine (R8) at the same peptide concentration
Macropinocytosis
In vitro
CCCHHHHHHHCCCSSCC
Additional Detail Fields 1 fields
CCCHHHHHHHCCCSSCC