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Peptide record

TPDB62764

NLS 1 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62764
NLS 1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KPRRNRKNKKQKQKQQ
Physicochemical Analysis
C87H161N37O23
ADCEGHILMFSTWYV
K
2093.47
12.72
9
0
0
+9
11.98
-3.719
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
6
Residue Composition
number
0
A
3
R
2
N
0
D
0
C
0
E
4
Q
0
G
0
H
0
I
0
L
6
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 0 C: 0 E: 0 Q: 4 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C87H161N37O23
2093.47
12.72
+9
11.98
-3.719
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T , Huh7, Bhk21, And Vero Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
FITC-labelled
Nucleus
NLS1 peptide efficiently deliver DNA inside the cell.
In vitro
CCTTSSCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T , Huh7, Bhk21, And Vero Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
GFP-tagged plasmid DNA
Nucleus
transfection efficiency was 13.7 ± 2.4% for the NLS1 peptide, and this transfected membrane penetration ability of the NLS1 peptide is not affected by the peptide: cell ratio as well as cell type.
In vitro
CCCTTTSCSSTHHHHC
Additional Detail Fields 1 fields
CCTTSSCCCCC CCCTTTSCSSTHHHHC