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Peptide record

TPDB62762

FMK Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62762
FMK
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KPLGLAGCRGDK
Physicochemical Analysis
C51H91N17O15S1
NEQHIMFSTWYV
G
1214.45
9.90
3
1
3
+2
2.97
-0.558
73.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
1
D
1
C
0
E
0
Q
3
G
0
H
0
I
2
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C51H91N17O15S1
1214.45
9.90
+2
2.97
-0.558
Free
L
Linear
Free
N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nih 3T3 Mouse Embryonic Fibroblast Cells And 4T1 Murine Breast Tumor Cells (Multicellular Spheroids (Mcss))

Assay & Model

Female BALB/c mice (4- to 6-weeks-old)
Female BALB/c mice (4- to 6-weeks-old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
TB NPs, IR820, and aPD-L1 encapsulated nanogels (aP/IR@FMKB)
aP/IR@FMKB combined with laser irradiation enhance the penetration of therapeutic agents into the tumor through the CRGDK motif.
In-vitro, in-vivo and ex vivo
CCCC
Additional Detail Fields 1 fields
CCCC