Back to search

Peptide record

TPDB62761

hPP3 Cell-penetrating Peptides modified_plain modified
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB62761
hPP3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 16-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
KPKRKRRKKKGHGWSR
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
16 main sequence record
Free Activity
L Activity
Linear Activity
Conjugated with FITC Activity
N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)O N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O Activity
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ecv304, Caski ,Mg63,Cos7, Hepg2Hsc-T6 , B16 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Protein derived
FITC-conjugated
Cytoplasm and nucleus
At 10 μM, the fluorescence was apparent but significantly weaker compared with TAT-FITC and with 5% DMSO uptake was significantly increased.
Clathrin-independent endocytic pathway
In vitro
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Primary Cultured Mouse Spleen Cells And. B16 Melanoma Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
GFP protein
Cytoplasm and nucleus
hPP10-GFP fusion protein uptake efficiency was similar with TAT-GFP treatment in ECV304 and Cos7 cells
Clathrin-independent endocytic pathway
In vitro
CCCTTGGGGCSCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Caski Cells Or Hsc-T6 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
KLA or NBD protein
Cytoplasm and nucleus
Clathrin-independent endocytic pathway
In vitro
CCCTTGGGGCSCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Caski , A2780, Mg63, Hsc-T7

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
FITC dye
Endocytosis
In vitro
CCCCCSCBTTBC
Additional Detail Fields 1 fields
CCCTTGGGGCSCCCC CCCCCSCBTTBC