TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB62721

Peptide_Name

CPP7

Activity

Cell-penetrating Peptides Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0 MLCPP 2.0 Peptipedia TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.

Sequence

KLWMRWWSPTTRRYG

FASTA

>TPDB62721|Cell-penetrating Peptides;Tumor-homing Peptides|length=15
KLWMRWWSPTTRRYG

Formula C95H138N28O20S1

Absent Amino Acids ANDCEQHIFV

Common Amino Acids RW

Mass 2024.38

PI 12.12

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +4

Boman Index -2.99

Hydrophobicity -1.327

Aliphatic Index 26.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 17990

Absorbance 280nm 888.67

Polar Residues 4

number

0

A

3

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

1

K

1

M

0

F

1

P

1

S

2

T

3

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 1 F: 0 P: 1 S: 1 T: 2 W: 3 Y: 1 V: 0

Length

15

Formula

C95H138N28O20S1

Mass

2024.38

PI

12.12

Net Charge

+4

Boman Index

-2.99

Hydrophobicity

-1.327

Chirality

L

Linearity

Linear

SMILES

N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line

Many Human neoplastic cells including HeLa, Lovo, A549, MCF-7,MKN45,HepG2, LNCap, KPK,U2OS, RC-15,RD-ES,H28,K562,U251,NHDF

Assay & Model

In Vitro Model NOD-SCID mice model of xenograft human tumour cells

In Vivo Model NOD-SCID mice model of xenograft human tumour cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Fluorophore (FITC)

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCCCSSCCCCCC

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Target Tumor Mesothelioma

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems

Year 2012

Reference

Eisaku Kondo et al. Nat Commun. 2012 Jul 17:3:951.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo H28

InVivo Model 7-week-old NOD-SCID mouse

Source Type mRNA display library

DSSP_Secondary_Structure

CCCCCCCSSCCCCCC

InVitro_ExVivo

H28

InVivo_Model

7-week-old NOD-SCID mouse