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Peptide record

TPDB62717

CCMV GAG Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB62717
CCMV GAG
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with fluorescein by C-terminal Gly Cys amide
Sequence
KLTRAQRRAAARKNKRNTRGC
Physicochemical Analysis
C98H183N45O27S1
DEHIMFPSWYV
R
2455.88
12.71
9
0
5
+9
8.06
-1.786
37.62
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
6
Residue Composition
number
4
A
6
R
2
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
1
L
3
K
0
M
0
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 6 N: 2 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 3 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C98H183N45O27S1
2455.88
12.71
+9
8.06
-1.786
Conjugation with fluorescein by C-terminal Gly Cys amide
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

RAW 264.7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus
Moderate relative to Tat-(48–60) peptide
Non-endocytic mechanism
In vitro
CCCTTTTTSCCCCCCTTTTTC
Additional Detail Fields 1 fields
CCCTTTTTSCCCCCCTTTTTC