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Peptide record

TPDB62714

BipM–AR₈ Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62714
BipM–AR₈
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-KLPVMARRRRRRRR-NH2
Physicochemical Analysis
C78H151N39O15S1
NDCEQGHIFSTWY
R
1907.37
13.25
9
0
4
+9
7.03
-2.129
55.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C78H151N39O15S1
1907.37
13.25
+9
7.03
-2.129
Amidation
L
Cationic
Linear
Acetylation
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nih/3 T3 And HeLa Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Plasmid DNA pSF-CMV-SEAP (OG105)
Not effective as a CPP for plasmid DNA delivery.
In vitro
CCCSSCSSSSSSCC
Additional Detail Fields 1 fields
CCCSSCSSSSSSCC