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Peptide record

TPDB62711

G55-9 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB62711
G55-9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
KLPCRSNTFLNIFRRKKPG-NH2
Physicochemical Analysis
C102H171N33O24S1
ADEQHMWYV
RK
2275.75
12.14
6
0
5
+6
3.49
-0.900
61.58
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
3
R
2
N
0
D
1
C
0
E
0
Q
1
G
0
H
1
I
2
L
3
K
0
M
2
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 3 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C102H171N33O24S1
2275.75
12.14
+6
3.49
-0.900
Amidation
L
Linear
Conjugation with fluorescein
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human SH-SY5Y, N2A and Human bowes melanoma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
In vitro
CCCCCCCSHHHHTTCCCCC
Additional Detail Fields 1 fields
CCCCCCCSHHHHTTCCCCC