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Peptide record

TPDB62710

KL4 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB62710
KL4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KLLLLKLLLLKLLLLKLLLLK-NH2
Physicochemical Analysis
C126H238N26O22
ARNDCEQGHIMFPSTWYV
L
2469.44
11.12
5
0
16
+5
-4.01
1.967
297.14
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
16
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 16 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C126H238N26O22
2469.44
11.12
+5
-4.01
1.967
Amidation
L
Cationic
Linear
Free
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
DY547-labeled siRNA nanoparticles
the KL4/siRNA complexes had significantly lower cellular uptake compared to Lipofectamine 2000/siRNA complexes (95% uptake) , but in presence of 1 mg/ml of Infasurf for KL4/siRNA complexes uptake decreased from 70% to just over 40% while that for when Lipofectamine 2000/siRNA complexes reduced to below 5%.
Clathrin mediated endocytosis
In vitro
CHHHHHHHHHTTCCSSSCCCC
Additional Detail Fields 1 fields
CHHHHHHHHHTTCCSSSCCCC