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Peptide record

TPDB62706

CB5005-Cys Blood-Brain Barrier Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62706
CB5005-Cys
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 22-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine
Sequence
KLKLALALALAVQRKRQKLMPC
Physicochemical Analysis
C112H206N34O25S2
NDEGHIFSTWY
L
2493.20
11.63
6
0
12
+6
2.75
0.245
137.73
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
4
A
2
R
0
N
0
D
1
C
0
E
2
Q
0
G
0
H
0
I
6
L
4
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 6 K: 4 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C112H206N34O25S2
2493.20
11.63
+6
2.75
0.245
Addition of Cysteine
L
Hydrophobic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 Cells

Assay & Model

U87 xenografts-bearing Male Nude mice weighing 20g
U87 xenografts-bearing Male Nude mice weighing 20g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
PEGylated liposomes loaded with doxorubicin (DOX) or FAM (dye)
Nucleus
99% FAM-positive percentage for CB5005-LS/FAM while 1% for LS/FAM or free FAM
In vitro and in vivo
CCCCSCCCHHHHHHHHTTSSCC
Additional Detail Fields 1 fields
CCCCSCCCHHHHHHHHTTSSCC