Back to search

Peptide record

TPDB62705

CB5005 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62705
CB5005
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KLKLALALALAVQRKRQKLMP
Physicochemical Analysis
C109H201N33O24S1
NDCEGHIFSTWY
L
2390.06
12.44
6
0
12
+6
2.99
0.138
144.29
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
4
A
2
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
6
L
4
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 6 K: 4 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C109H201N33O24S1
2390.06
12.44
+6
2.99
0.138
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3, U87 Excised Mice Brain

Assay & Model

Nude mice model bearing U87 xenograft
Nude mice model bearing U87 xenograft

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
5-carboxyfluorescein (FAM) dye and Doxorubicin (DOX)
Cytoplasm and nucleus
At 5 µM CB5005-FAM, the percentages of FAM-positive cells were 68.7% for bEnd.3 cells and 78.9% for U87 cells,
Endocytosis
In-vitro, in-vivo and ex vivo
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC