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Peptide record

TPDB62704

CB5005M Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB62704
CB5005M
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KLKLALALALA
Physicochemical Analysis
C54H101N13O12
RNDCEQGHIMFPSTWYV
L
1124.48
10.60
2
0
9
+2
-1.50
1.673
213.64
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C54H101N13O12
1124.48
10.60
+2
-1.50
1.673
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3, U87 Excised Mice Brain

Assay & Model

Nude mice model bearing U87 xenograft
Nude mice model bearing U87 xenograft

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
5-carboxyfluorescein (FAM) dye and Doxorubicin (DOX)
Cytoplasm
CB5005M-FAM could be internalized by U87 cells
Endocytosis
In-vitro, in-vivo and ex vivo
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC