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Peptide record

TPDB62694

PepH2 Blood-Brain Barrier Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62694
PepH2
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 14-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KLFMALVAFLRFLT
Physicochemical Analysis
C83H132N18O16S1
NDCEQGHIPSWY
L
1670.13
11.49
2
0
11
+2
-4.19
1.729
146.43
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
1
K
1
M
3
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 1 M: 1 F: 3 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C83H132N18O16S1
1670.13
11.49
+2
-4.19
1.729
Free
L
Linear
Hydrophobic
Linear
Free
Similarity
Cationic
LysLeuPheMetAlaLeuValAlaPheLeuArgPheLeuThr
N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

bEND cell line

Assay & Model

5 microCi/ml
Gamma counter radioactivity measure for TcPz
9.32+/- 2.50
Origin/Source

Source & Reference

NA
B3Pdb

Other

Derived from dengue virus capsid
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
Evidence 2 Activity

Activity

Blood-Brain Barrier

Target

bEND cell line

Assay & Model

5 microCi/ml
Gamma counter radioactivity measure for gaNODA
13.51 +/- 0.70
Origin/Source

Source & Reference

NA
B3Pdb

Other

Derived from dengue virus capsid
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
Evidence 3 Activity

Activity

Blood-Brain Barrier
9.32%

Assay & Model

Initial concentration in donor chamber-Culture
Origin/Source
Translocated

Source & Reference

NA
B3Pdb

Other

fungal
Permeability
99mTc(CO)3+
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Protein derived
Radiolabelled using fac-[99mTc(CO)3(H2O)3]+ and 67-Ga-labeled
PepH2 presented high cellular internalization (42.7±0.0 % after 24 h) but BEB translocation was reduced (9.2±2.5 % after 24 h)
In vitro
CCSSTTTCCC
Additional Detail Fields 1 fields
CCSSTTTCCC