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Peptide record

TPDB62686

KLA-ECP(32-41) Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62686
KLA-ECP(32-41)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Sequence
KLAKLAKKLAKLAKNYRWRCKNQN
Physicochemical Analysis
C130H224N42O30S1
DEGHIMFPSTV
K
2887.53
11.26
9
0
10
+9
4.44
-1.150
81.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
242.08
6
Residue Composition
number
4
A
2
R
3
N
0
D
1
C
0
E
1
Q
0
G
0
H
0
I
4
L
7
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 3 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 4 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
24
C130H224N42O30S1
2887.53
11.26
+9
4.44
-1.150
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Beas-2B, A549, Caco-2 and AGS

Assay & Model

Female Sprague-Dawley rats
Female Sprague-Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
Peptide (KLA)
In vitro and in vivo
CTHHHHHHHHHHTTTSCCSCSCCC
Additional Detail Fields 1 fields
CTHHHHHHHHHHTTTSCCSCSCCC