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Peptide record

TPDB62684

TAT-PAD Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB62684
TAT-PAD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KLAKLAKKLAKLAKGGYGRKKRRQRRR
Physicochemical Analysis
C140H260N54O30
NDCEHIMFPSTWV
K
3179.95
12.72
14
0
9
+14
9.53
-1.548
72.59
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
46.86
2
Residue Composition
number
4
A
6
R
0
N
0
D
0
C
0
E
1
Q
3
G
0
H
0
I
4
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 4 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
27
C140H260N54O30
3179.95
12.72
+14
9.53
-1.548
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, HeLa, Hepg2 And MCF-7/Adr Cells

Assay & Model

Female Nu/nu nude mice bearing MCF-7 breast cancer xenografts.
Female Nu/nu nude mice bearing MCF-7 breast cancer xenografts.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Pro-apoptotic peptide (PAD)
Near The Plasma Membrane
CsA-PAD internalization was higher in MCF-7, HeLa and HepG2 cells, and at similar level in MCF-7/Adr cells in comparison to TAT-PAD
In vitro and in vivo
CTHHHHHHHHHHTTCSCCTTGGGSCCC
Additional Detail Fields 1 fields
CTHHHHHHHHHHTTCSCCTTGGGSCCC