Back to search

Peptide record

TPDB62679

PEG-Tat-KK Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62679
PEG-Tat-KK
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: PEGylation Chemical: Nanoparticle N-terminal: Addition of dipeptide KK
Sequence
KKYGRKKRRQRRR
Physicochemical Analysis
C76H142N36O16
ANDCEHILMFPSTWV
R
1816.20
12.71
10
0
1
+10
8.47
-3.677
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
82.04
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C76H142N36O16
1816.20
12.71
+10
8.47
-3.677
PEGylation
Nanoparticle
L
Cationic
Linear
Addition of dipeptide KK
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2 Cells

Assay & Model

H22 tumor-bearing male KM mice (body weight 18-22 g)
H22 tumor-bearing male KM mice (body weight 18-22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
Doxorubicin (DOX)
Nuclei
At pH 6.8, the intracellular MFI of DGL-PEG-Tat-KK-DMA-DOX (4087) was significantly increased and its value was much higher than that of DOX (1711) and DGL-PEG-Tat-DOX (2893).
In vitro and in vivo