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Peptide record

TPDB62669

LNP Blood-Brain Barrier Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62669
LNP
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict Peptipedia CPPsite3.0
standard
No
A 14-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict, Peptipedia, and CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with CF Via GGG Linker
Sequence
KKRTLRKNDRKKRC
Physicochemical Analysis
C75H144N32O19S1
AEQGHIMFPSWYV
K
1830.23
12.01
9
1
1
+8
9.18
-2.779
27.86
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
4
R
1
N
1
D
1
C
0
E
0
Q
0
G
0
H
0
I
1
L
5
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 1 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 5 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C75H144N32O19S1
1830.23
12.01
+8
9.18
-2.779
Free
L
Linear
Conjugated with CF Via GGG Linker
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC/D3 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
CF dye
#2077 and LNP peptides, showed significantly lower permeability than FD-4
In vitro
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC