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Peptide record

TPDB62662

Peptide 4 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB62662
Peptide 4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KKPPWLKLDI-NH2
Physicochemical Analysis
C61H100N14O13
ARNCEQGHMFSTYV
K
1237.55
10.32
3
1
4
+2
1.82
-0.720
117.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
444.43
0
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
3
K
0
M
0
F
2
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 3 M: 0 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
10
C61H100N14O13
1237.55
10.32
+2
1.82
-0.720
Amidation
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hl-60 And Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
The uptake of the original peptide (1) and its shorter derivatives (4 and 5) was poor
In vitro
CCCSSSSCCC
Additional Detail Fields 1 fields
CCCSSSSCCC