Back to search

Peptide record

TPDB62655

BP100CH7 BPCH7 BPLH7 Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62655
BP100CH7 BPCH7 BPLH7
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KKLFKKILKYLHHCRGHTVHSHHHCIR
Physicochemical Analysis
C152H242N52O31S2
ANDEQMPW
H
3358.04
10.76
14
0
8
+8
8.79
-0.804
82.96
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1615
48.09
5
Residue Composition
number
0
A
2
R
0
N
0
D
2
C
0
E
0
Q
1
G
7
H
2
I
3
L
5
K
0
M
1
F
0
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 7 I: 2 L: 3 K: 5 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
27
C152H242N52O31S2
3358.04
10.76
+8
8.79
-0.804
Free
L
Cyclic Linear
Free
NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Leaves Of Wild-Type Or Transgenic A. Thaliana Plants

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Fusogenic
pDNA (encoding GFP with cyanine fluorescent dye (Cy3))
Cytoplasm and nucleus
Internalization and detection of BPCH7−Cy3pDNA was observed after 15−30 min of incubation.In the absence of BPCH7, no internalization of Cy3pDNA in cells even when available in excess amounts
Clathrin mediated endocytosis
In vitro
CCCBTTBCCCCSSCCCCCCCSSCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Leaves Of Wild-Type Or Transgenic A. Thaliana Plants

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Fusogenic
pDNA (encoding GFP with cyanine fluorescent dye (Cy3))
Vacuole
Accumulation of BPKH−Cy3pDNA complexes in the vacuole lumen of cells, in striking contrast to the BPCH7−Cy3pDNA complexes
Clathrin mediated endocytosis
In vitro
CTTHHHHHHHSSCSCCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

O. Sativa Callus Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Fusogenic
Citrine (yellow fluorescent protein)
Cell Membrane and Cytoplasm
BP100(KH)9 and BP100CH7 were similar in delivery efficiency of Citrine protein into 5-day rice callus cells
Endocytosis
In vitro
CCCCCCCCCC
Additional Detail Fields 1 fields
CCCBTTBCCCCSSCCCCCCCSSCCCCC CTTHHHHHHHSSCSCCCCCC CCCCCCCCCC