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Peptide record

TPDB62653

BP100-Cys Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62653
BP100-Cys
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: MAL-TEG-PLL/pDNA micelle
Sequence
KKLFKKILKYLC
Physicochemical Analysis
C75H129N17O14S1
ARNDEQGHMPSTWV
K
1525.01
10.48
5
0
6
+5
0.65
0.033
130.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
97.70
2
Residue Composition
number
0
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
1
I
3
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C75H129N17O14S1
1525.01
10.48
+5
0.65
0.033
Addition of Cysteine
MAL-TEG-PLL/pDNA micelle
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Leaves Of N. Benthamiana

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
pDNA (p35S-Nluc-tNOS)
Nucleus
The efficiency of BP100-48 (2144 ± 420 RLU/mg) was higher than that of the micelles co-modified with BP100-Cys and Cys-NLS(BP100-24/NLS-24 and BP100-48/NLS-24 578 ±196 RLU/mg)
In vitro
CTTHHHHHHHSSCSCCCCCC
Additional Detail Fields 1 fields
CTTHHHHHHHSSCSCCCCCC