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Peptide record

TPDB62643

ch-K5R8 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB62643
ch-K5R8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Angiopep-2 conjugated micelles N-terminal: Conjugated with CHOlesterol
Sequence
KKKKKRRRRRRRR
Physicochemical Analysis
C78H158N42O14
ANDCEQGHILMFPSTWYV
R
1908.39
13.25
13
0
0
+13
11.43
-4.269
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C78H158N42O14
1908.39
13.25
+13
11.43
-4.269
Free
Angiopep-2 conjugated micelles
L
Cationic
Linear
Conjugated with CHOlesterol
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293 Cells, Bcecs And U251 Cells

Assay & Model

Male BALB/c nude mice (18–22 g) and male BALB/c mice (18–22 g)
Male BALB/c nude mice (18–22 g) and male BALB/c mice (18–22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
YOYO-1 labelled pEGFP
Nucleus
EGFP fluorescence intensity was higher than ch-K3(s-s)R8-An/pEGFP and naked pDNA
In vitro and in vivo
CCSGGGGCCCCCC
Additional Detail Fields 1 fields
CCSGGGGCCCCCC