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Peptide record

TPDB62642

p10 P1 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB62642
p10 P1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
KKKKKRFSFKKSFKLSGFSFKKNKK
Physicochemical Analysis
C147H243N41O31
ADCEQHIMPTWYV
K
3080.80
12.07
13
0
6
+13
7.43
-1.624
15.60
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
12
K
0
M
5
F
0
P
4
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 12 M: 0 F: 5 P: 0 S: 4 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C147H243N41O31
3080.80
12.07
+13
7.43
-1.624
Free
L
Linear
Conjugated with FITC
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC/C=C\CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C/C(=C/C)/C=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF7, A549, Bv2 Cell Line, And T6 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
plasmid DNA pdsRed
Cytoplasm
P1 has a higher penetration efficiency than MT23 and TAT
Direct penetration and Receptor-mediated endocytosis
In vitro
CCCCCCEETTEECSSSCCCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hsc-T6 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Oleanolic acid (OA) and FITC dye
Fluorescence can be shown to be well-distributed throughout the cytoplasm, enhanced by DMSO and sugar.
Direct translocation
In vitro
CCCCGGGGTSCCCSSSSCCC
Additional Detail Fields 1 fields
CCCCCCEETTEECSSSCCCCCCCCC CCCCGGGGTSCCCSSSSCCC