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Peptide record

TPDB62641

K5(QW)6K5 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62641
K5(QW)6K5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KKKKKQWQWQWQWQWQWKKKKK
Physicochemical Analysis
C156H230N44O29
ARNDCEGHILMFPSTYV
K
3185.82
11.46
10
0
6
+10
2.28
-2.973
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
33000
1035.84
6
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
6
Q
0
G
0
H
0
I
0
L
10
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 6 G: 0 H: 0 I: 0 L: 0 K: 10 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
22
C156H230N44O29
3185.82
11.46
+10
2.28
-2.973
Free
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And Hek293 Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Hoechst 33258 dye and FITC-labeled luciferase gene
Nucleus
Moderate increase of intracellular fluorescence. Transfection efficiency of K5(QW)6K5 is ~400 fold less than that of K10(QW)6 in HEK293 cell line and ~200 fold less in HeLa cell line
In vitro
CCCCCCCTTCCSCC
Additional Detail Fields 1 fields
CCCCCCCTTCCSCC