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Peptide record

TPDB62639

P6 Cell-penetrating Peptides modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB62639
P6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 18-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Modified, details unspecified
Sequence
KKKKKQBKKKHRWPKXXC
Physicochemical Analysis
C90H159N31O17S1
ANDEGILMFSTYV
K
1979.51
11.37
11
0
1
+10
9.62
-2.572
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
277.85
2
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
1
Q
0
G
1
H
0
I
0
L
9
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 0 K: 9 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C90H159N31O17S1
1979.51
11.37
+10
9.62
-2.572
Free
Modified
Cationic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa 654 Cells

Assay & Model

EGFP-654 transgenic mice
EGFP-654 transgenic mice

Source & Reference

CPPsite3.0
CPPsite3
WO2020028254A1, WO2019178479A1, WO2019079386A1,WO2019079367A0

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified Cationic
Synthetic
PMO anti-IVS2-660 and diphtheria toxin A (DTA)
Cytosol and Nucleus
Receptor mediated endocytosis
In vitro and in vivo