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Peptide record

TPDB62627

K10-E2 Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62627
K10-E2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KKKKKKKKKKQWQWQWQWQWQWEE
Physicochemical Analysis
C166H244N46O35
ARNDCGHILMFPSTYV
K
3444.05
10.88
10
2
6
+8
6.32
-3.017
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
33000
958.17
6
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
2
E
6
Q
0
G
0
H
0
I
0
L
10
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 6 G: 0 H: 0 I: 0 L: 0 K: 10 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
24
C166H244N46O35
3444.05
10.88
+8
6.32
-3.017
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FITC
Cytoplasm
K10-E3 showed the highest fluorescence intensity, followed by K10-E2 and K12-E3 which have comparable fluorescence.
Macropinocytosis
In vitro
CCCCCCCCCCCSSCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCSSCCCCCCCCCCC