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Peptide record

TPDB62625

K12-E3 Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB62625
K12-E3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KKKKKKKKKKKKQWQWQWQWQWQWEEE
Physicochemical Analysis
C183H275N51O40
ARNDCGHILMFPSTYV
K
3829.51
10.81
12
3
6
+9
10.32
-3.100
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
33000
861.73
6
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
3
E
6
Q
0
G
0
H
0
I
0
L
12
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 3 Q: 6 G: 0 H: 0 I: 0 L: 0 K: 12 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
27
C183H275N51O40
3829.51
10.81
+9
10.32
-3.100
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FITC
Cytoplasm
K10-E3 showed the highest fluorescence intensity, followed by K10-E2 and K12-E3 which have comparable fluorescence.
Macropinocytosis
In vitro
CCCCTTCCSSSCCCCCSSCCSSCSCCC
Additional Detail Fields 1 fields
CCCCTTCCSSSCCCCCSSCCSSCSCCC