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Peptide record

TPDB62624

K16ApoE Cell-penetrating Peptides standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB62624
K16ApoE
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 36-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: PLGA nanoparticles
Sequence
KKKKKKKKKKKKKKKKLRVRLASHLRKLRKRLLRDA-NH2
Physicochemical Analysis
C204H392N74O40
NCEQGIMFPTWY
K
4521.83
12.74
25
1
9
+23
21.37
-2.058
78.61
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
6
R
0
N
1
D
0
C
0
E
0
Q
0
G
1
H
0
I
6
L
18
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 6 K: 18 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
36
C204H392N74O40
4521.83
12.74
+23
21.37
-2.058
Amidation
PLGA nanoparticles
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC/D3 Cells

Assay & Model

DutchAβ40 treated WT mice
DutchAβ40 treated WT mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
AF647-labelled IgG4.1
The K16ApoE-targeted nanoparticles showed 8- to 10-fold higher accumulation in hCMEC/D3 cells and various brain regions of DutchAβ40 treated WT mice as compared to the targeted nanoparticles without K16ApoE
In vitro and in vivo
CCCCCCC
Additional Detail Fields 1 fields
CCCCCCC