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Peptide record

TPDB62613

Cyt C 86-101 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62613
Cyt C 86-101
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: N-terminal acylation of peptide with 6-carboxy-tetramethylrhodamine
Sequence
KKKEERADLIAYLKKA-NH2
Physicochemical Analysis
C86H150N24O24
NCQGHMFPSTWV
K
1904.28
10.20
6
3
7
+3
8.15
-1.144
91.88
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
78.24
1
Residue Composition
number
3
A
1
R
0
N
1
D
0
C
2
E
0
Q
0
G
0
H
1
I
2
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 1 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
16
C86H150N24O24
1904.28
10.20
+3
8.15
-1.144
Amidation
L
Linear
N-terminal acylation of peptide with 6-carboxy-tetramethylrhodamine
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U373MG cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (6-carboxy-tetramethylrhodamine)
Nucleus
Low (< 10 fold uptake)
In vitro
CCCCGGGTTTTTTTCC
Additional Detail Fields 1 fields
CCCCGGGTTTTTTTCC