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Peptide record

TPDB62607

LAH4 Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB62607
LAH4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-KKALLALALHHLAHLALHLALALKKAGC-NH2
Physicochemical Analysis
C137H236N40O29S1
RNDEQIMFPSTWYV
L
2939.69
10.55
8
0
18
+4
0.61
0.932
167.86
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
8
A
0
R
0
N
0
D
1
C
0
E
0
Q
1
G
4
H
0
I
10
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 4 I: 0 L: 10 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C137H236N40O29S1
2939.69
10.55
+4
0.61
0.932
Amidation
L
Amphipathic
Linear
Acetylation
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Embryonic Kidney-Derived Cells 293Tt , 3T6 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
VLPs*(MPyV virus-like particles labeled with Alexa Fluor 488)
Significantly lower relative MFI was detected than control VLPs*
Endocytosis
In vitro
CCCCCCCCSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Human Embryonic Kidney-Derived Cells 293Tt , 3T6 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
PsVs of MPyV(SV40 and MusPV)
10-fold for MPyV PsVs at 10 μM and 3-fold for SV40 PsVs at 5 μM of viral transduction after coincubation with LAH4.
Endocytosis
In vitro
CCSSHHHHHHHHHHHHHHHCC
Additional Detail Fields 1 fields
CCCCCCCCSCC CCSSHHHHHHHHHHHHHHHCC