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Peptide record

TPDB62606

LAH4 Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB62606
LAH4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KKALLALALHHLAHLALHLALALKKAC
Physicochemical Analysis
C135H233N39O28S1
RNDEQGIMFPSTWYV
L
2882.64
10.55
8
0
18
+4
0.60
0.981
174.07
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
8
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
4
H
0
I
10
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 10 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
27
C135H233N39O28S1
2882.64
10.55
+4
0.60
0.981
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)/N=C/C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat Cells And Mouse Primary T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
AAV6-green fluorescent protein (AAV6-GFP)
LAH4 at 0.2 mM resulted in a two-fold increase in transduction efficiency (from 17.9% to 38.1%,p < 0.05).
Macropinocytosis and other mechanism
In vitro
CCCCGGGSCCSSSCBCCCSSSSCBSSGGGTC
Additional Detail Fields 1 fields
CCCCGGGSCCSSSCBCCCSSSSCBSSGGGTC