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Peptide record

TPDB62605

LAH5 Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB62605
LAH5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanocomplexe
Sequence
KKALLALALHHLAHLAHHLALALKKA
Physicochemical Analysis
C132H224N40O27
RNDCEQGIMFPSTWYV
L
2803.48
11.00
9
0
17
+4
2.36
0.654
165.77
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
5
H
0
I
9
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 5 I: 0 L: 9 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26
C132H224N40O27
2803.48
11.00
+4
2.36
0.654
Free
Nanocomplexe
L
Amphipathic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T, HeLa , Hepg2 And Primary Fibroblast Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphipathic
Protein derived
Cas9 RNP (Cas9-GFP with ATTO-550-labelled sgRNA) and ssDNA HDR
Cytosol And Nucleolar
Large increase in cell-associated fluorescence was observed, with both Cas9-GFP and ATTO-550-sgRNA co-localizing inside the cells compared to without LAH5 which show mo signals.
Endocytosis
In vitro