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Peptide record

TPDB62603

HBHAc Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB62603
HBHAc
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC-labeled
Sequence
KKAAPAKKAAAKKAPAKKAAAKK
Physicochemical Analysis
C103H191N33O24
RNDCEQGHILMFSTWYV
A
2275.86
11.46
10
0
11
+10
8.93
-0.974
47.83
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
11
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
10
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 11 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 10 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
23
C103H191N33O24
2275.86
11.46
+10
8.93
-0.974
Free
FITC-labeled
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, MDA-MB-231, And PC3 Cells

Assay & Model

Female athymic nude mice (Hsd:Athymic Nude-Foxn1 n, 4–6 weeks old)
Female athymic nude mice (Hsd:Athymic Nude-Foxn1 n, 4–6 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Arginine deiminase (ADI)
Uptake amount of HBHAc-ADI was significantly higher (1.2-fold difference between normoxic versus hypoxic conditions) than ADI PEG20 and ADI
In vitro and in vivo
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC