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Peptide record

TPDB62602

hPP10 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB62602
hPP10
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KIPLPRFKLKCIFCKKRRKR
Physicochemical Analysis
C118H208N38O21S2
ANDEQGHMSTWYV
K
2559.31
12.02
10
0
6
+10
5.60
-0.870
78.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
125
4.88
2
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
2
I
2
L
6
K
0
M
2
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 6 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C118H208N38O21S2
2559.31
12.02
+10
5.60
-0.870
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16, Ecv304, Hepg2, Or Caski Cells (

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
pcDNA3.1-GFP plasmid
Cytosol and Nucleus
Transfection efficiency obtained from hPP10 was higher than the efficiency from TAT.
In vitro
CCCCCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

B16, Ecv304, Hepg2, Or Caski Cells (

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
pcDNA3.1-LGluc plasmid
Cytosol and Nucleus
Transfection efficiency obtained from hPP10 was higher than the efficiency from TAT.
In vitro
CCSCCSSSSCCCCCSCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Caski Cells , B16, Ecv304. Hepg2, T24, L929, Hsc-T6, Caski And Thp1

Assay & Model

C57BL/6 mice bearing subcutaneous melanoma tumors
C57BL/6 mice bearing subcutaneous melanoma tumors

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC, GFP, Apoptin , catalytic subunit (GCLC)
Cytoplasm and nucleus
hPP10- FITC and TAT-FITC were taken up by Caski cells, and hPP10-FITC was long-lasting fluorescence than TAT-FITC
Endocytosis
In vitro and in vivo
CGGGGGGSCCCSCCCCTTHHHHSGGGTTSSGGGCCSCSSCC
Additional Detail Fields 1 fields
CCCCCCCCCCC CCSCCSSSSCCCCCSCCCCC CGGGGGGSCCCSCCCCTTHHHHSGGGTTSSGGGCCSCSSCC