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Peptide record

TPDB62599

dNP2 Blood-Brain Barrier Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62599
dNP2
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 22-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
Sequence
KIKKVKKKGRKKIKKVKKKGRK
Physicochemical Analysis
C122H240N42O23
ANDCEQHLMFPSTWY
K
2663.52
12.52
16
0
4
+16
15.02
-2.136
61.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
0
L
14
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 14 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
22
C122H240N42O23
2663.52
12.52
+16
15.02
-2.136
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat T Cells, Primary Mouse Splenocytes And Human PBMCs

Assay & Model

C57BL/6 mice
C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Cytotoxic T-lymphocyte antigen 4 (ctCTLA-4)
Cytoplasm and nucleus
dNP2-EGFP displayed 62.4% EGFP-positive cells, while the cells treated with TAT-EGFP or EGFP alone showed 16.6 and 2.59% EGFP-positive cells,
Endocytosis pathways (including lipid raft-mediated endocytosis following heparan sulphate interaction)
In vitro and in vivo
CCCCCCTTCC
Additional Detail Fields 1 fields
CCCCCCTTCC