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Peptide record

TPDB62598

dNP2 Blood-Brain Barrier Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62598
dNP2
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 24-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KIKKVKKKGRKGSKIKKVKKKGRK
Physicochemical Analysis
C127H248N44O26
ANDCEQHLMFPTWY
K
2807.65
12.52
16
0
4
+16
15.16
-2.008
56.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
0
L
14
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 0 K: 14 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C127H248N44O26
2807.65
12.52
+16
15.16
-2.008
Free
L
Linear
Free
Similarity
Cationic
N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

Jurkat cells

Assay & Model

2 μM
Confocal microscopy
dNP2 enables the delivery of LRR domain of NLRX1 into T cells
Origin/Source
Confocal microscopy
dNP2 enables the delivery of LRR domain of NLRX1 into T cells
Encephalomyelitis

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intraperitoneal
It directly inhibits the functions of effector T cells and ameliorates disease severity of EAE with
Combined with LRR
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat T Cells, HeLa Cells

Assay & Model

10-week-old female C57BL/6 mice
10-week-old female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Leucine-rich repeat domain (LRR) of NLRX1
Cytoplasm And Nucleus (Small Amount In Mitochondria)
dNP2-LRR showed dose-dependent increase in efficiency of intracellular delivery, which was significantly higher than either TAT-LRR or LRR alone.
In vitro and in vivo
CCCTTSCCCC
Additional Detail Fields 2 fields
CCCTTSCCCC
Intraperitoneal